反应详情

To a solution of the compound (1 g, 2.79 mmol) obtained in Step (i) in methanol (2 ml) was added a 4N-hydrochloric acid in dioxane (2 ml), and the mixture was stirred at room temperature for 3.5 hours. The mixture was neutralized by addition of 28% aqueous ammonia at 0° C., and the mixture was stirred for one hour. The precipitated crystals were collected by filtration, washed twice with water (2 ml) and further washed twice with methanol (2 ml), and dried to give the subtitle compound (882 mg) as a white solid. Yield: 92%

1. stirringthe mixture was stirred for one hour
2. filtrationThe precipitated crystals were collected by filtration
3. washwashed twice with water (2 ml)
4. washfurther washed twice with methanol (2 ml)
5. customdried