HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1666200Generated: October 25, 2026
Potassium Carbonate → 2-Butoxy-7,8-dihydro-9-(3-[4-(4-methylbenzyl)piperazin-1-yl]propyl)-8-oxoadenine
https://huagongshe.com/reaction/1666200
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(4-Methylbenzyl)piperazine | HCID 764723 | — |
| Reactant | 2-Butoxy-9-(3-bromopropyl)-7,8-dihydro-8-oxoadenine | HCID 59288031 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Butoxy-7,8-dihydro-9-(3-[4-(4-methylbenzyl)piperazin-1-yl]propyl)-8-oxoadenine | HCID 25014764 | 20.2% |
Reaction Steps
The compound (180 mg) obtained in Step (ii), potassium carbonate (140 mg) and 4-methylbenzylpiperazine (130 mg) were added to DMF (5 mL), and the mixture was stirred at 70° C. for 3 hours. The insoluble materials were collected by filtration, and the residue was purified by silica gel column chromatography (CHCl3:MeOH:28% NH3 aq.=100:3:2) to give the title compound (48 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08044056B2 |
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| Source dataset | uspto-grants-2011_10 |
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| ORD ID | ord-b86f59bebe9f499f8c4dc1a19f62f9de |
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| Source note | uspto-grants-2011_10 |
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