Potassium Carbonate → 9-(1-tert-Butoxycarbonylpiperidin-4-ylethyl)-8-methoxy-2-(2-methoxyethoxy)adenine

Participants

Reaction Conditions

Reaction Steps

8-Methoxy-2-(2-methoxyethoxy)adenine (3.27 g, 13.7 mmol) was dissolved in DMF (75 ml), and thereto were added potassium carbonate (1.89 g, 13.7 mmol) and 4-[2-(methanesulfonyloxy)ethyl]piperidine-1-carboxylic acid tert-butyl ester (4.21 g, 13.7 mmol), and the mixture was stirred at 60° C. for 2.5 hours. The mixture was cooled to room temperature, and the carbonate salt was removed by filtration, and the filtrate was concentrated. To the residue was added water, and the mixture was extracted three times with chloroform. The resultant was dried over magnesium sulfate, and concentrated. The residue was purified by silica gel column (chloroform/methanol=200/1 to 100/1) to give the subtitle compound (3.62 g, 8.04 mmol) as a white solid. Yield: 60%.

Provenance & Evidence