Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | 9-{2-[1-(4-Dimethylaminomethylbenzyl)piperidin-4-yl]ethyl}-8-methoxy-2-(2-methoxyethoxy)-9H-purin-6-ylamine | HCID 59288030 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 25014850 | HCID 25014850 | 65% |
Reaction Steps
To the compound (0.28 g, 0.57 mmol) obtained in Step (iii) were added methanol (3 ml) and a 4N hydrochloric acid in dioxane (3 ml), and the mixture was stirred at room temperature for one hour. The mixture was cooled to 0° C., and neutralized with 4% aqueous ammonia. The precipitated solid was collected by filtration, and washed with water to give the title compound (0.18 g, 0.19 mmol) as a white solid. Yield: 65%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08044056B2 |
|---|
| Source dataset | uspto-grants-2011_10 |
|---|
| ORD ID | ord-4e02a590dbb04076b28f715169bb35b8 |
|---|
| Source note | uspto-grants-2011_10 |
|---|
