Ammonia → HCID 25014850, compound

HRID 1666206Notes

Reaction equation

HRID 1666206 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[CH:36]=[CH:35][C:8]([CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([CH2:16][CH2:17][N:18]3[C:26]([O:27]C)=[N:25][C:24]4[C:19]3=[N:20][C:21]([O:30][CH2:31][CH2:32][O:33][CH3:34])=[N:22][C:23]=4[NH2:29])[CH2:12][CH2:11]2)=[CH:7][CH:6]=1)[CH3:3].CO.Cl.N>O1CCOCC1>[NH2:29][C:23]1[N:22]=[C:21]([O:30][CH2:31][CH2:32][O:33][CH3:34])[N:20]=[C:19]2[C:24]=1[NH:25][C:26](=[O:27])[N:18]2[CH2:17][CH2:16][CH:13]1[CH2:14][CH2:15][N:10]([CH2:9][C:8]2[CH:7]=[CH:6][C:5]([CH2:4][N:2]([CH3:1])[CH3:3])=[CH:36][CH:35]=2)[CH2:11][CH2:12]1

Participants

6

Reactant 4

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 887MethanolHCID 592880309-{2-[1-(4-Dimethylaminomethylbenzyl)piperidin-4-yl]ethyl}-8-methoxy-2-(2-methoxyethoxy)-9H-purin-6-ylamine

Product 1

HCID 25014850HCID 25014850, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
0 °C

Procedure

To the compound (0.28 g, 0.57 mmol) obtained in Step (iii) were added methanol (3 ml) and a 4N hydrochloric acid in dioxane (3 ml), and the mixture was stirred at room temperature for one hour. The mixture was cooled to 0° C., and neutralized with 4% aqueous ammonia. The precipitated solid was collected by filtration, and washed with water to give the title compound (0.18 g, 0.19 mmol) as a white solid. Yield: 65%.

Workup

  1. filtrationThe precipitated solid was collected by filtration
  2. washwashed with water

Sources & evidence

ORD record
ord-4e02a590dbb04076b28f715169bb35b8
Source dataset
uspto-grants-2011_10
Patent number
US08044056B2

Reaction notes

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