反应详情

温度

100 °C

To a solution of 3-(3,4-dimethoxyphenyl)propynoic acid (6-amino-1-ethyl-3-prop-2-ynyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)amide (3.2 g, 8.0 mmol) in 15 ml of dry dimethylformamide was added phosphorous pentoxide (6 g). The mixture was stirred at 100° C. for 10 min and subsequently cooled to room temperature. The product was precipitated by adding water (ca. 100 ml), filtered under reduced pressure, washed thoroughly with water and dried at 70° C., yielding light yellow 8-(3,4-dimethoxyphenylethynyl)-3-ethyl-1-prop-2-ynyl-3,7-dihydro-purine-2,6-dione (2.5 g, 82%).

1. temperaturesubsequently cooled to room temperature
2. customThe product was precipitated
3. additionby adding water (ca. 100 ml)
4. filtrationfiltered under reduced pressure
5. washwashed thoroughly with water
6. customdried at 70° C.