Potassium Carbonate → 2-amino-8-ethyl-6-ethynyl-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one

HRID 1666274Notes

Reaction equation

HRID 1666274 reaction equation
C(=O)([O-])[O-].[K+].[K+].[NH2:7][C:8]1[N:9]=[C:10]([CH3:27])[C:11]2[CH:17]=[C:16]([C:18]#[C:19][Si](C)(C)C)[C:15](=[O:24])[N:14]([CH2:25][CH3:26])[C:12]=2[N:13]=1>CO>[NH2:7][C:8]1[N:9]=[C:10]([CH3:27])[C:11]2[CH:17]=[C:16]([C:18]#[CH:19])[C:15](=[O:24])[N:14]([CH2:25][CH3:26])[C:12]=2[N:13]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 576069742-amino-8-ethyl-4-methyl-6-((trimethylsilyl)ethynyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Product 1

HCID 576069672-amino-8-ethyl-6-ethynyl-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Potassium carbonate (1.00 g, 7.28 mmol) was added to a flask charged with 2-amino-8-ethyl-4-methyl-6-((trimethylsilyl)ethynyl)pyrido[2,3-d]pyrimidin-7(8H)-one (1.09 g, 3.64 mmol) in anhydrous methanol (15 mL). The reaction was stirred at room temperature under nitrogen for 16 h. The reaction was concentrated to one half volume and the yellow precipitate collected by vacuum filtration to afford 2-amino-8-ethyl-6-ethynyl-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one.

Workup

  1. concentrationThe reaction was concentrated to one half volume
  2. filtrationthe yellow precipitate collected by vacuum filtration

Sources & evidence

ORD record
ord-d33964636b834db582cf1e66b7594515
Source dataset
uspto-grants-2011_10
Patent number
US08044062B2

Reaction notes

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