HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-(3-Benzyloxy-benzylidene)-piperidine trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-(3-Benzyloxy-benzylidene)-piperidine-1-carboxylic acid tert-butyl ester | HCID 66876001 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(3-Benzyloxy-benzylidene)-piperidine trifluoroacetate | HCID 66876189 | — |
Reaction Steps
4-(3-Benzyloxy-benzylidene)-piperidine-1-carboxylic acid tert-butyl ester (534 mg, 1.4 mmol) from Step 2 was dissolved in CH2Cl2 (5 mL) and treated with trifluoroacetic acid (1.05 mL, 14.1 mmol). After 2 hours, the solution was concentrated to provide the title compound which was used without further purification (550 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044052B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-4fc2c6e0d9814ed1af959ba0dce20d27 |
| Source note | uspto-grants-2011_10 |