HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 4-oxopiperidine-1-carboxylate → 4-[3-(4-Fluoro-phenoxy)-benzylidene]-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| Reactant | [3-(4-Fluoro-phenoxy)-benzyl]-phosphonic acid diethyl ester | HCID 86623894 | — |
| Product | 4-[3-(4-Fluoro-phenoxy)-benzylidene]-piperidine-1-carboxylic acid tert-butyl ester | HCID 66876248 | 78.2% |
Reaction Steps
Following the procedure in Example 1, Step 4, using [3-(4-fluoro-phenoxy)-benzyl]-phosphonic acid diethyl ester (1.2 g, 3.5 mmol) (Step 1) and 4-oxo-piperidine-1-carboxylic acid tert-butyl ester (707 mg, 3.55 mmol) yielded the title compound (1.05 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044052B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-e91563922a8f484db0c65fbdc32574d7 |
| Source note | uspto-grants-2011_10 |