反应详情

To a solution of tert-butyl 4-(3-(5-(2,2,2-trifluoroethoxy)pyridin-2-yloxy)benzylidene)piperidine-1-carboxylate (0.36 g, 0.77 mmol) in CH2Cl2 (3 mL) cooled to 0° C. under a N2 atmosphere was added TFA (0.46 mL, 5.97 mmol). The resulting mixture was stirred for 2 h at RT. The solution was concentrated and then quenched with saturated NaHCO3 solution. The mixture was extracted with CH2Cl2 and the organic extract was dried over Na2SO4, and concentrated under reduced pressure to give the title compound (0.282 g, 99%). m/z (365.1, M+ H+).

1. concentrationThe solution was concentrated
2. customquenched with saturated NaHCO3 solution
3. extractionThe mixture was extracted with CH2Cl2
4. extractionthe organic extract
5. dry with materialwas dried over Na2SO4
6. concentrationconcentrated under reduced pressure