5-Bromo-2-chloropyrimidine → tert-Butyl 3-[(5-bromopyrimidin-2-yl)oxy]pyrrolidine-1-carboxylate

HRID 1666542Notes

Reaction equation

HRID 1666542 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH:10]([OH:13])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl[C:15]1[N:20]=[CH:19][C:18]([Br:21])=[CH:17][N:16]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH:10]([O:13][C:15]2[N:20]=[CH:19][C:18]([Br:21])=[CH:17][N:16]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 6066655-Bromo-2-chloropyrimidineHCID 44169391-Boc-3-pyrrolidinol

Product 1

HCID 23115998tert-Butyl 3-[(5-bromopyrimidin-2-yl)oxy]pyrrolidine-1-carboxylate

Procedure

According to the same method as in Example 1-1) but using 1-t-butoxycarbonyl-3-hydroxypyrrolidine and 2-chloro-5-bromopyrimidine, the entitled compound was obtained.

Workup

  1. customthe entitled compound was obtained

Sources & evidence

ORD record
ord-26981281c59e4c128ee79467f2cee48a
Source dataset
uspto-grants-2011_10
Patent number
US08044070B2

Reaction notes

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