4-Cyanophenylboronic acid → Benzonitrile, 4-[5-[(1-cyclopentyl-4-piperidinyl)oxy]pyrazinyl]-

HRID 1666552Notes

Reaction equation

HRID 1666552 reaction equation
C(O[C:6]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[N:19][C:18](Br)=[CH:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[C:22]([C:24]1[CH:29]=[CH:28][C:27](B(O)O)=[CH:26][CH:25]=1)#[N:23]>>[CH:6]1([N:8]2[CH2:9][CH2:10][CH:11]([O:14][C:15]3[CH:20]=[N:19][C:18]([C:27]4[CH:28]=[CH:29][C:24]([C:22]#[N:23])=[CH:25][CH:26]=4)=[CH:17][N:16]=3)[CH2:12][CH2:13]2)[CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 27343264-Cyanophenylboronic acidHCID 58456669Tert-butyl 4-(5-bromopyrazin-2-yloxy)piperidine-1-carboxylate

Product 1

HCID 11428018Benzonitrile, 4-[5-[(1-cyclopentyl-4-piperidinyl)oxy]pyrazinyl]-

Procedure

According to the same method as in Example 1-2), 3), 4) but using 2-(1-t-butoxycabonylpiperidin-4-yloxy)-5-bromopyrazine and 4-cyanophenylboronic acid, the entitled compound was obtained.

Workup

  1. customthe entitled compound was obtained

Sources & evidence

ORD record
ord-81a9130555c840deb28b314dc550ff64
Source dataset
uspto-grants-2011_10
Patent number
US08044070B2

Reaction notes

Loading…