Sodium Hydroxide → HCID 20240767, compound

HRID 1666704Notes

Reaction equation

HRID 1666704 reaction equation
C([O:3][C:4](=[O:16])[CH2:5][O:6][C:7]1[O:8][C:9]2[CH:15]=[CH:14][CH:13]=[CH:12][C:10]=2[N:11]=1)C.[OH-].[Na+]>O>[O:8]1[C:9]2[CH:15]=[CH:14][CH:13]=[CH:12][C:10]=2[N:11]=[C:7]1[O:6][CH2:5][C:4]([OH:16])=[O:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13950999HCID 13950999, compound

Product 1

HCID 20240767HCID 20240767, compoundYield 31.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The solution of 0.2 g (0.9 mmol) ethyl-(1,3-benzoxazol-2-yloxy)acetate and 0.4 g (1 mmol) sodium hydroxide in 1 ml water is stirred for 2 hours at room temperature, then extracted with 3×5 ml chloroform. The united organic phase is dried over sodium sulfate and evaporated in vacuum to obtain 54 mg title compound as an oil. LC-MS[MH+]=194 (C9H7NO4 193.16)

Workup

  1. extractionextracted with 3×5 ml chloroform
  2. dry with materialThe united organic phase is dried over sodium sulfate
  3. customevaporated in vacuum

Sources & evidence

ORD record
ord-2ec8c0500d234e478aa1793a6fa7e113
Source dataset
uspto-grants-2011_10
Patent number
US08044078B2

Reaction notes

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