Hydrochloric Acid → HCID 22607995, compound

HRID 1666792Notes

Reaction equation

HRID 1666792 reaction equation
[C:1]1([S:7][C:8]2[CH:9]=[C:10]([CH:14]3OCC[O:15]3)[CH:11]=[CH:12][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl>C(#N)C>[C:1]1([S:7][C:8]2[CH:9]=[C:10]([CH:11]=[CH:12][CH:13]=2)[CH:14]=[O:15])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19421799HCID 19421799, compound

Product 1

HCID 22607995HCID 22607995, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Combine 2-(3-phenylsulfanylphenyl)-[1,3]-dioxolane (0.3 g, 1.1 mmol) and acetonitrile (8.0 ml) add a solution of hydrochloric acid (1N, 2.0 ml). After 18 hours, concentrate in vacuum to remove most of the acetonitrile, dilute with water and extract with ether. Combine the organic extracts and wash once with saturated sodium bicarbonate, then with brine. Dry (Na2SO4) the organics, filter, and concentrated to give the title compound.

Workup

  1. concentrationconcentrate in vacuum
  2. customto remove most of the acetonitrile
  3. additiondilute with water
  4. extractionextract with ether
  5. washwash once with saturated sodium bicarbonate
  6. dry with materialDry (Na2SO4) the organics,
  7. filtrationfilter
  8. concentrationconcentrated

Sources & evidence

ORD record
ord-be77df34d0d448c1ad15b10ce592fbec
Source dataset
uspto-grants-2011_10
Patent number
US08044090B2

Reaction notes

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