HCID 17980129, compound → 2-Bromo-5-fluoro-4-methoxybenzenamine

HRID 1666812Notes

Reaction equation

HRID 1666812 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([F:10])=[CH:4][C:3]=1[N+:11]([O-])=O>C1COCC1>[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([F:10])=[CH:4][C:3]=1[NH2:11]

Participants

3

Reactant 1

HCID 17980129HCID 17980129, compound

Product 1

HCID 179763232-Bromo-5-fluoro-4-methoxybenzenamine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Combine 1-bromo-4-fluoro-5-methoxy-2-nitrobenzene (20.5 g, 82 mmol) and Pt-on-carbon (sulfided) in THF (600 mL) and hydrogenate at 60 psi (414 kPa) over for 4 hours. Filter the reaction through celite to remove the catalyst and remove the solvent to give 2-bromo-5-fluoro-4-methoxyaniline as a brown solid which may taken on without further purification.

Workup

  1. customover for 4 hours
  2. filtrationFilter
  3. customthe reaction through celite
  4. customto remove the catalyst
  5. customremove the solvent

Sources & evidence

ORD record
ord-08e825efa4394470a6a476521c4cae2f
Source dataset
uspto-grants-2011_10
Patent number
US08044090B2

Reaction notes

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