HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1666872Generated: October 30, 2026
3-Hydroxybenzaldehyde → 3-Propoxybenzaldehyde
https://huagongshe.com/reaction/1666872
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Hydroxybenzaldehyde | HCID 101 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Iodopropane | HCID 33643 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-Propoxybenzaldehyde | HCID 2760469 | — |
Reaction Steps
Combine 3-hydroxybenzaldehyde (790 g), K2CO3, (1627 g) and DMF (8 L). Add 1-iodopropane (1000 g) and heat to 105° C. and stir for 4 h. Cool to about 50° C. and add water (15 L), continue cooling to about room temperature and add toluene (10 L). Separate the organic layer and extract the aqueous phase with toluene (2×10 L), combine organic phases and wash with NaOH 1N (2×5.8 L), concentrate the combined organic layers in vacuo to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08044090B2 |
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| Source dataset | uspto-grants-2011_10 |
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| ORD ID | ord-2d24e54df193457bb3feb4908fa8a161 |
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| Source note | uspto-grants-2011_10 |
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