反应详情

Combine 4-phenoxy-1-methyl-2-nitro-benzene (6 g, 26.2 mmol) and DMF dimethylacetal (15.6 g, 131 mmol) in 60 mL dry DMF and heat at 170° C. for 16 hours. Cool to room temperature and concentrate to dryness. Dissolve residue in 50 mL EtOAc and hydrogenate with 2 g 5% Pd/C and hydrogen for 3 hours at atmospheric pressure. Filter through celite and concentrate to an oil. Purify by chromatography using Hex/EtoAC to obtain a tan solid: ISMS 210 (M+1)

1. concentrationconcentrate to dryness
2. filtrationFilter through celite
3. concentrationconcentrate to an oil
4. customPurify by chromatography
5. customto obtain a tan solid