Sodium Sulfate → HCID 21071426, compound

HRID 1666892Notes

Reaction equation

HRID 1666892 reaction equation
Cl.[Cl:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([CH2:12][CH2:13][NH2:14])=[CH:8][NH:9]2)=[CH:5][CH:4]=1.C(N(C(C)C)C(C)C)C.[F:24][CH:25]([F:36])[CH2:26][O:27][C:28]1[CH:29]=[C:30]([CH:33]=[CH:34][CH:35]=1)[CH:31]=O.S([O-])([O-])(=O)=O.[Na+].[Na+].[BH4-].[Na+]>C(O)C>[Cl:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([CH2:12][CH2:13][NH:14][CH2:31][C:30]3[CH:33]=[CH:34][CH:35]=[C:28]([O:27][CH2:26][CH:25]([F:24])[F:36])[CH:29]=3)=[CH:8][NH:9]2)=[CH:5][CH:4]=1

Participants

7

Reactant 5

HCID 24436Sodium SulfateHCID 81531DiisopropylethylamineHCID 4311764Sodium borohydrideHCID 210714533-(2,2-difluoroethoxy)benzaldehydeHCID 22256592HCID 22256592, compound

Product 1

HCID 21071426HCID 21071426, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
78 °C

Procedure

Combine 2-(6-chloro-1H-indol-3-yl)ethylamine hydrochloride (1.0 g, 4.3 mmol) and ethyldiisopropylamine (900 μL, 5.2 mmol) in ethanol (150 mL) and stir at room temperature and treat with 3-(2,2-difluoroethoxy)benzaldehyde (856 mg, 4.6 mmol) and anhydrous sodium sulfate (12 g) and heat at 78° C. overnight. Cool to room temperature and filter. Treat the resulting filtrate with sodium borohydride (488 mg, 12.9 mmol) and stir the milky-white mixture at room temperature overnight. Remove in vacuo the solvent, and purification of the crude on silica gel eluting with 10% methanol in dichloromethane gives the free base of the title compound as a light yellow oil. Dissolve a portion of the oil (651 mg, 1.78 mmol) in methanol (15 mL) and treat with a homogenous solution of ammonium chloride (95 mg, 1.78 mmol) in methanol (3 mL). Sonicate the resulting solution for 10 minutes before removal of the solvent in vacuo to provide an off-white solid. Triturate with diethyl ether containing a few drops of acetonitrile. Filtration and drying of the precipitate afforded the title hydrochloride as a white solid: mp 131.6-133° C.; 1H NMR (400 MHz, dmso-d6): 11.15 (br s, 1H), 9.50 (br s, 2H), 7.57 (d, 1H, J=8.8 Hz), 7.39 (d, 1H, J=2.0 Hz), 7.36 (t, 1H, J=8.2 Hz), 7.32 (br s, 1H), 7.26 (d, 1H, J=2.0 Hz), 7.17 (d, 1H, J=7.6 Hz), 7.04 (dd, 1H, J=7.8, 2.2 Hz), 7.01 (dd, 1H, J=8.4, 2.0 Hz), 6.41 (tt, 1H, J=54.4, 3.4 Hz), 4.32 (td, 2H, J=14.8, 3.6 Hz), 4.14 (br s, 2H), 3.11 (br s, 4H); MS (ES+): m/e 365.3 (M+1); CHN (for C19H19F2ClN2.O.HCl.0.3H20) calcd: C, 56.11; H, 5.11; N, 6.89. found: C, 56.03; H, 4.95; N, 7.18.

Workup

  1. temperatureCool to room temperature
  2. filtrationfilter
  3. customRemove in vacuo
  4. customthe solvent, and purification of the crude on silica gel eluting with 10% methanol in dichloromethane

Sources & evidence

ORD record
ord-d5cac1cf329a467884138bfef67c5497
Source dataset
uspto-grants-2011_10
Patent number
US08044090B2

Reaction notes

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