反应详情

温度

120 °C

2-(2-Aminoanilino)-5-methylthiophene-3-carbonitrile (10.0 g) is taken in N-methyl-piperazine (60 ml) and N-methyl-piperazine hydrochloride (24 gm). The solution is heated at 120° C. until completion of reaction. The reaction mass is cooled and dichloromethane (100 ml) and water is added. The mixture is cooled up to room temperature and dichloromethane layer is separated. 50 ml dichloromethane is evaporated and cyclohexane is added in clear solution. On Cooling the solution, solid is separated out, which is filtered and dried under vacuum to get Olanzapine Form I. (Purity >99.6%)

1. temperatureThe reaction mass is cooled
2. temperatureThe mixture is cooled up to room temperature
3. customdichloromethane layer is separated
4. custom50 ml dichloromethane is evaporated
5. additioncyclohexane is added in clear solution
6. temperatureOn Cooling the solution, solid
7. customis separated out
8. filtrationwhich is filtered
9. customdried under vacuum