Thionyl Chloride → 2,4-Difluoro-3-methoxybenzoyl chloride

HRID 1666968Notes

Reaction equation

HRID 1666968 reaction equation
[F:1][C:2]1[C:10]([O:11][CH3:12])=[C:9]([F:13])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:16])=O>C(OCC)(=O)C>[F:1][C:2]1[C:10]([O:11][CH3:12])=[C:9]([F:13])[CH:8]=[CH:7][C:3]=1[C:4]([Cl:16])=[O:5]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 37805552,4-Difluoro-3-methoxybenzoic acid

Product 1

HCID 38506192,4-Difluoro-3-methoxybenzoyl chloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 2,4-difluoro-3-methoxybenzoic acid (2.1 g, 11.1 mmol), thionyl chloride (5 mL), and ethyl acetate (30 mL) is refluxed for 4 h. All volatiles are removed in vacuo, and the remaining residue is used directly in the next synthetic step.

Workup

  1. temperatureis refluxed for 4 h
  2. customAll volatiles are removed in vacuo

Sources & evidence

ORD record
ord-fa2eee3b14c54461ab380684b254c85f
Source dataset
uspto-grants-2011_10
Patent number
US08044204B2

Reaction notes

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