反应详情

A solution of 0.11 g (0.24 mmol) of ethyl (S)-3-(6-aminopyridin-3-yl)-2-{1-[5-(5-chlorothiophen-2-yl)isoxazol-3-ylmethyl]-1H-imidazol-4-yl}propionate in 2 ml of semi-concentrated hydrochloric acid was stirred at RT for 24 h. The reaction mixture was freeze-dried and purified by preparative HPLC. The fractions of value obtained were combined and freeze-dried with 2 equivalents (eq) of 1N HCl (1×) and with 1 eq of 1N HCl and water (1×). This gave 0.077 g (69%) of the title compound as the hydrochloride.

1. customThe reaction mixture was freeze-dried
2. custompurified by preparative HPLC
3. customThe fractions of value obtained