反应详情

温度

225 °C

3,3-Diphenyldihydrofuran-2(3H)-one (3.98 g, 16.70 mmol) and zinc chloride (0.080 g) were placed in an autoclave. Ammonia (8 mL) was added, and the reactor was sealed and heated at 225° C. for 21 hours under an argon atmosphere at an equilibrium pressure of 800 pounds per square inch. The vessel was cooled, the ammonia was vented, and a mixture of solids was obtained. The solid was treated with ethanol (100 mL), filtered and concentrated. Silica gel chromatography eluting with 5% methanol/dichloromethane gave the title compound. MS (DCI+) m/z 238.1 (M+H)+.

1. customthe reactor was sealed
2. temperatureThe vessel was cooled
3. additiona mixture of solids
4. customwas obtained
5. filtrationfiltered
6. concentrationconcentrated
7. washSilica gel chromatography eluting with 5% methanol/dichloromethane