反应详情

温度

75 °C

To a solution of 3,3-bis(4-fluorophenyl)pyrrolidin-2-one (Example 58B, 1.37 g, 5.00 mmol) in tetrahydrofuran (30 mL) was added potassium t-butoxide (1.0 M in tetrahydrofuran) (7.5 mL, 7.5 mmol) followed by the product from Example 63A (1.47 g, 5.00 mmol). The reaction mixture was heated at 75° C. for 18 hours. The reaction was concentrated, diluted with ethyl acetate, washed with water and brine, dried with MgSO4, filtered and concentrated. The residue was purified with silica gel chromatography eluting with 3% methanol/dichloromethane to give the title compound. MS (DCI) m/z 486.3 (M+H)+.

1. concentrationThe reaction was concentrated
2. additiondiluted with ethyl acetate
3. washwashed with water and brine
4. dry with materialdried with MgSO4
5. filtrationfiltered
6. concentrationconcentrated
7. customThe residue was purified with silica gel chromatography
8. washeluting with 3% methanol/dichloromethane