Hydrochloric Acid → 1-[[3-(Trifluoromethyl)phenyl]sulfonyl]piperazine

HRID 1667161Notes

Reaction equation

HRID 1667161 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[CH:4]=[C:5]([S:9]([N:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1.Cl>O1CCOCC1>[F:25][C:2]([F:1])([F:26])[C:3]1[CH:4]=[C:5]([S:9]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)(=[O:10])=[O:11])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 46180376HCID 46180376, compound

Product 1

HCID 23056121-[[3-(Trifluoromethyl)phenyl]sulfonyl]piperazine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The product from Example 84A (2.75 g, 6.97 mmol) was dissolved in dioxane (10 mL) with sonication. To the solution was added hydrochloric acid (4.0 Min dioxane) (5.23 mL, 20.92 mmol), and the reaction was allowed to stir at room temperature. After stirring for 4 hours, the reaction was concentrated. This residue was triturated with diethyl ether with sonication to give a solid which was collected by filtration to give the title compound as the hydrochloride salt.

Workup

  1. stirringAfter stirring for 4 hours
  2. concentrationthe reaction was concentrated
  3. customThis residue was triturated with diethyl ether with sonication
  4. customto give a solid which
  5. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-6bee682f96364334b1516e344ddd6685
Source dataset
uspto-grants-2011_10
Patent number
US08044069B2

Reaction notes

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