1-(Diphenylmethyl)-4-piperidinamine → HCID 67444020, compound

HRID 1667162Notes

Reaction equation

HRID 1667162 reaction equation
[O:1]=[C:2]1[C:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:6][CH2:5][CH2:4][N:3]1[CH2:20][C:21](O)=[O:22].[CH:24]([N:37]1[CH2:42][CH2:41][CH:40]([NH2:43])[CH2:39][CH2:38]1)([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[CH:24]([N:37]1[CH2:42][CH2:41][CH:40]([NH:43][C:21](=[O:22])[CH2:20][N:3]2[CH2:4][CH2:5][CH2:6][C:7]([C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=3)([C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:2]2=[O:1])[CH2:39][CH2:38]1)([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 128755351-(Diphenylmethyl)-4-piperidinamineHCID 673592802-(2-Oxo-3,3-diphenylpiperidin-1-yl)acetic acid

Product 1

HCID 67444020HCID 67444020, compound

Procedure

The title compound was prepared as described in Example 28B, reacting 2-(2-oxo-3,3-diphenylpiperidin-1-yl)acetic acid (Example 68E) with 1-benzhydrylpiperidin-4-amine (Example 48A). 1H NMR (300 MHz, CDCl3) δ ppm 7.14-7.43 (m, 20H), 6.58 (d, J=8.1 Hz, 1H), 4.24 (s, 1H), 4.01 (s, 2H), 3.72-3.84 (m, 1H), 3.53 (t, J=6.4 Hz, 2H), 2.70-2.77 (m, 2H), 2.58-2.63 (m, 2H), 1.97-2.08 (m, 2H), 1.76-1.91 (m, 5H), 1.41-1.50 (m, 1H); MS (ESI+) m/z 558 (M+H)+.

Sources & evidence

ORD record
ord-a4457cf654a74707a4653e4b951fb698
Source dataset
uspto-grants-2011_10
Patent number
US08044069B2

Reaction notes

Loading…