Trifluoroacetic acid → HCID 67446670, compound

HRID 1667166Notes

Reaction equation

HRID 1667166 reaction equation
[CH3:1][C@@:2]12[CH2:10][N:9]([C:11](=[O:32])[CH2:12][N:13]3[CH2:18][CH2:17][CH2:16][C:15]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[C:14]3=[O:31])[CH2:8][C@@H:7]1[CH2:6][CH2:5][CH2:4][N:3]2C(OC(C)(C)C)=O.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:1][C@@:2]12[CH2:10][N:9]([C:11](=[O:32])[CH2:12][N:13]3[CH2:18][CH2:17][CH2:16][C:15]([C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=4)([C:19]4[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=4)[C:14]3=[O:31])[CH2:8][C@@H:7]1[CH2:6][CH2:5][CH2:4][NH:3]2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67444438HCID 67444438, compound

Product 1

HCID 67446670HCID 67446670, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product from Example 88A was dissolved in methylene chloride and reacted with trifluoroacetic acid at ambient temperature for 1 hour. The reaction mixture was concentrated to yield the trifluoroacetic salt of the title compound. m/z 418 (M+H)+.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-eff6334980dd4082ba2c563bf607c481
Source dataset
uspto-grants-2011_10
Patent number
US08044069B2

Reaction notes

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