1,4-Dioxane hydrochloride → HCID 67359480, compound

HRID 1667224Notes

Reaction equation

HRID 1667224 reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:4]=[C:5]([CH:20]=[CH:21][CH:22]=1)[CH2:6][N:7]1[CH2:11][CH2:10][C@H:9]([NH:12]C(=O)OC(C)(C)C)[CH2:8]1.[ClH:25].O1CCOCC1>CO>[ClH:25].[F:23][C:2]([F:1])([F:24])[C:3]1[CH:4]=[C:5]([CH:20]=[CH:21][CH:22]=1)[CH2:6][N:7]1[CH2:11][CH2:10][C@H:9]([NH2:12])[CH2:8]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 67443239HCID 67443239, compound

Product 1

HCID 67359480HCID 67359480, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of product from Example 185A (0.32 g, 0.9 mmol) in methanol (10 mL) was treated with 4 N HCl/dioxane (2 mL) for 2 hours at room temperature. The reaction mixture was concentrated to yield the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 7.60 (m, 3H), 6.99 (m, 1H), 3.93 (m, 1H), 3.64 (dd, 2H), 2.69 (m, 1H), 2.45 (m, 2H), 2.26 (m, 1H), 1.99 (m, 1H), 1.60 (m, 1H); MS (ESI+) m/z 244 (M+H)+.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-a8327b76d93b424e9fa15c61bab12aff
Source dataset
uspto-grants-2011_10
Patent number
US08044069B2

Reaction notes

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