3,3-Diphenylpyrrolidine → HCID 57396818, compound

HRID 1667286Notes

Reaction equation

HRID 1667286 reaction equation
O=C1C(C2C=CC=CC=2)(C2C=CC=CC=2)CCCN1CC(O)=O.F[C:25]1[CH:30]=[CH:29][C:28]([C:31]2([C:42]3[CH:47]=[CH:46][C:45](F)=[CH:44][CH:43]=3)[CH2:36][CH2:35][CH2:34][N:33]([CH2:37][C:38](O)=[O:39])[C:32]2=[O:41])=[CH:27][CH:26]=1.[F:49][C:50]([F:62])([F:61])[C:51]1[CH:60]=[C:59]2[C:54]([CH2:55][CH2:56][NH:57][CH2:58]2)=[CH:53][CH:52]=1.C1(C2(C3C=CC=CC=3)CCNC2)C=CC=CC=1>>[O:39]=[C:38]([N:57]1[CH2:56][CH2:55][C:54]2[C:59](=[CH:60][C:51]([C:50]([F:49])([F:62])[F:61])=[CH:52][CH:53]=2)[CH2:58]1)[CH2:37][N:33]1[CH2:34][CH2:35][CH2:36][C:31]([C:28]2[CH:27]=[CH:26][CH:25]=[CH:30][CH:29]=2)([C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)[C:32]1=[O:41]

Participants

5

Reactant 4

HCID 4182423,3-DiphenylpyrrolidineHCID 103755517-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinolineHCID 673591112-(3,3-Bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetic acidHCID 673592802-(2-Oxo-3,3-diphenylpiperidin-1-yl)acetic acid

Product 1

HCID 57396818HCID 57396818, compound

Procedure

The title compound was prepared using the procedure described in Example 172 substituting 2-(2-oxo-3,3-diphenylpiperidin-1-yl)acetic acid from Example 68E for 2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetic acid and 7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline for 3,3-diphenylpyrrolidine. 1H NMR (300 MHz, CDCl3) δ ppm 7.43 (d, J=9.3, 2H), 7.36-7.15 (m, 11H), 4.74 (d, J=40.6, 2H), 4.31 (s, 2H), 3.88 (t, J=5.9, 1H), 3.70 (t, J=5.9, 1H), 3.54 (t, J=6.4, 2H), 2.93 (t, J=5.8, 2H), 2.72-2.56 (m, 2H), 1.93-1.81 (m, 2H); MS (DCI) m/z 493.1 (M+H)+.

Sources & evidence

ORD record
ord-33176af53aee4ea7880ba53ad3261579
Source dataset
uspto-grants-2011_10
Patent number
US08044069B2

Reaction notes

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