3,3-Diphenylpyrrolidine → HCID 57396818, compound

Participants

Reaction Steps

The title compound was prepared using the procedure described in Example 172 substituting 2-(2-oxo-3,3-diphenylpiperidin-1-yl)acetic acid from Example 68E for 2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetic acid and 7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline for 3,3-diphenylpyrrolidine. 1H NMR (300 MHz, CDCl3) δ ppm 7.43 (d, J=9.3, 2H), 7.36-7.15 (m, 11H), 4.74 (d, J=40.6, 2H), 4.31 (s, 2H), 3.88 (t, J=5.9, 1H), 3.70 (t, J=5.9, 1H), 3.54 (t, J=6.4, 2H), 2.93 (t, J=5.8, 2H), 2.72-2.56 (m, 2H), 1.93-1.81 (m, 2H); MS (DCI) m/z 493.1 (M+H)+.

Provenance & Evidence