反应详情

2-(4-(Trifluoromethyl)phenyl)acetic acid (5.0 g, 24.49 mmol) was dissolved in ethanol (100 mL). Concentrated sulfuric acid (1 mL) was added, and the mixture was refluxed overnight. After cooling to room temperature, the reaction mixture was concentrated and diluted with diethyl ether. The organic solvent solution was then extracted with water, saturated aqueous sodium bicarbonate solution, and brine. The organic layer was then dried with magnesium sulfate, filtered, and concentrated to obtain the title compound. MS (DCI+) m/z 250 (M+NH4)+.

1. temperaturethe mixture was refluxed overnight
2. concentrationthe reaction mixture was concentrated
3. additiondiluted with diethyl ether
4. extractionThe organic solvent solution was then extracted with water, saturated aqueous sodium bicarbonate solution, and brine
5. dry with materialThe organic layer was then dried with magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated