HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → tert-Butyl 3-cyano-8-azabicyclo[3.2.1]octane-8-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Tosylmethyl isocyanide | HCID 161915 | — |
| Reactant | tert-Butyl 3-oxo-8-azabicyclo(3.2.1)octane-8-carboxylate | HCID 2794767 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | tert-Butyl 3-cyano-8-azabicyclo[3.2.1]octane-8-carboxylate | HCID 53487658 | — |
Reaction Steps
tert-Butyl 3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate was reacted in the presence of p-toluenesulfonylmethylisocyanide, potassium tert-butoxide and ethanol in 1,2-dimethoxyethane to produce tert-butyl 3-cyano-8-azabicyclo[3.2.1]octane-8-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044206B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-8d3fee58ebb643c39eb5fe5a85e4f451 |
| Source note | uspto-grants-2011_10 |