Ethanol, 2,2'-(1,2-ethanediyldiimino)bis- → 3,6-Diazaoctane-1,8-diol, 3,6-bis(t-butoxycarbonyl)-

HRID 1667329Notes

Reaction equation

HRID 1667329 reaction equation
[OH:1][CH2:2][CH2:3][NH:4][CH2:5][CH2:6][NH:7][CH2:8][CH2:9][OH:10].[O:11](C(OC(C)(C)C)=O)[C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=O>CO>[C:12]([N:4]([CH2:3][CH2:2][OH:1])[CH2:5][CH2:6][N:7]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:11])[CH2:8][CH2:9][OH:10])([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:11]

Participants

4

Reactant 2

HCID 78179Ethanol, 2,2'-(1,2-ethanediyldiimino)bis-HCID 90495Di-tert-butyl dicarbonate

Product 1

HCID 5541023,6-Diazaoctane-1,8-diol, 3,6-bis(t-butoxycarbonyl)-

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The product was prepared by treating N,N′-bis(2-hydroxyethyl)ethylenediamine in methanol with (BOC)2O at room temperature. The reaction mixture was chilled to −15° C. to −20° C. to precipitate the product. After filtration, the precipitate was desiccated to yield the product.

Workup

  1. customThe product was prepared
  2. temperatureThe reaction mixture was chilled to −15° C. to −20° C.
  3. customto precipitate the product
  4. filtrationAfter filtration
  5. customto yield the product

Sources & evidence

ORD record
ord-2e77d5e36cf647eab3872c8b16032bdf
Source dataset
uspto-grants-2011_10
Patent number
US08044215B2

Reaction notes

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