HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Phenylglycine → Tert-butyl (2s)-{[2-(4-{6-amino-5-[(4-fluorophenyl)carbonyl]-2-oxopyridin-1(2h)-yl}phenyl)ethyl]amino}(phenyl)ethanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Phenylglycine | HCID 99291 | — |
| Reactant | Methanesulfonic acid 2-{4-[6-amino-5-(4-fluoro-benzoyl)-2-oxo-2H-pyridin-1-yl]-phenyl}-ethyl ester | HCID 58608538 | — |
| Product | Tert-butyl (2s)-{[2-(4-{6-amino-5-[(4-fluorophenyl)carbonyl]-2-oxopyridin-1(2h)-yl}phenyl)ethyl]amino}(phenyl)ethanoate | HCID 57658465 | — |
Reaction Steps
From Intermediate 4J and L-Phenylglycine tbutyl ester. LC/MS: m/z 542 [M+H]+. 1H NMR (300 MHz, CDCl3) δ: 10.30 (1H, br s), 7.51-7.45 (3H, m), 7.38 (2H, d, J=6.9 Hz), 7.27-7.04 (9H, m), 5.82 (1H, d, J=9.6 Hz), 4.20 (1H, s), 2.86-2.75 (4H, m), 2.04 (1H, br s), 1.31 (9H, s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044211B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-1e827f433fd549eb9b02387ade5be87f |
| Source note | uspto-grants-2011_10 |