HRID1667383

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID99291

L-Phenylglycine

C8H9NO2

结构：CS(=O)(=O)OCCc1ccc(-n2c(N)c(C(=O)c3ccc(F)cc3)ccc2=O)cc1

HCID58608538

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)[C@@H](NCCc1ccc(-n2c(N)c(C(=O)c3ccc(F)cc3)ccc2=O)cc1)c1ccccc1

HCID57658465

未命名化合物

PROCEDURE

实验过程

From Intermediate 4J and L-Phenylglycine tbutyl ester. LC/MS: m/z 542 [M+H]+. 1H NMR (300 MHz, CDCl3) δ: 10.30 (1H, br s), 7.51-7.45 (3H, m), 7.38 (2H, d, J=6.9 Hz), 7.27-7.04 (9H, m), 5.82 (1H, d, J=9.6 Hz), 4.20 (1H, s), 2.86-2.75 (4H, m), 2.04 (1H, br s), 1.31 (9H, s).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1e827f433fd549eb9b02387ade5be87f
来源数据集: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08044211B2
来源说明: uspto-grants-2011_10

反应 SMILES

[NH2:1][C:2]1[N:7]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15]OS(C)(=O)=O)=[CH:10][CH:9]=2)[C:6](=[O:21])[CH:5]=[CH:4][C:3]=1[C:22](=[O:30])[C:23]1[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=1.[CH:31]1[CH:36]=[CH:35][C:34]([C@H:37]([NH2:41])[C:38]([OH:40])=[O:39])=[CH:33][CH:32]=1>>[NH2:1][C:2]1[N:7]([C:8]2[CH:9]=[CH:10][C:11]([CH2:14][CH2:15][NH:41][C@@H:37]([C:34]3[CH:33]=[CH:32][CH:31]=[CH:36][CH:35]=3)[C:38]([O:40][C:3]([CH3:22])([CH3:4])[CH3:2])=[O:39])=[CH:12][CH:13]=2)[C:6](=[O:21])[CH:5]=[CH:4][C:3]=1[C:22]([C:23]1[CH:24]=[CH:25][C:26]([F:29])=[CH:27][CH:28]=1)=[O:30]