HRID1667384

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14938987

2-(3-Aminophenyl)ethan-1-ol

C8H11NO

HCID53718217

未命名化合物

2 次

结构：CS(=O)(=O)OCCc1ccc(-n2c(N)c(C(=O)c3ccc(F)cc3)ccc2=O)cc1

HCID58608538

未命名化合物

PRODUCTS

生成物

结构：CC(C)C[C@H](NCCc1cccc(-n2c(N)c(C(=O)c3ccc(F)cc3)ccc2=O)c1)C(=O)OC1CCCC1

HCID57658334

未命名化合物

PROCEDURE

实验过程

Example 70 was synthesised using similar methodology to Intermediate 4J (instead using 3-aminophenethyl alcohol) and L-Leucine cyclopentyl ester (Intermediate 8).

WORKUP

后处理

customExample 70 was synthesised

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-734c844e101f480aa573bb3fe8d82c39
来源数据集: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08044211B2
来源说明: uspto-grants-2011_10

反应 SMILES

[NH2:1][C:2]1[N:7]([C:8]2[CH:13]=[CH:12][C:11](CCOS(C)(=O)=O)=[CH:10][CH:9]=2)[C:6](=[O:21])[CH:5]=[CH:4][C:3]=1[C:22](=[O:30])[C:23]1[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=1.N[C:32]1C=C(C=C[CH:40]=1)CCO.[CH:41]1([O:46][C:47](=[O:54])[C@H:48]([CH2:50][CH:51]([CH3:53])[CH3:52])[NH2:49])[CH2:45][CH2:44][CH2:43][CH2:42]1>>[NH2:1][C:2]1[N:7]([C:8]2[CH:13]=[C:12]([CH2:32][CH2:40][NH:49][C@H:48]([C:47]([O:46][CH:41]3[CH2:42][CH2:43][CH2:44][CH2:45]3)=[O:54])[CH2:50][CH:51]([CH3:52])[CH3:53])[CH:11]=[CH:10][CH:9]=2)[C:6](=[O:21])[CH:5]=[CH:4][C:3]=1[C:22]([C:23]1[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=1)=[O:30]