HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(3-Aminophenyl)ethan-1-ol → Cyclopentyl N-[2-(3-{6-amino-5-[(4-fluorophenyl)carbonyl]-2-oxopyridin-1(2H)-yl}phenyl)ethyl]-L-leucinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(3-Aminophenyl)ethan-1-ol | HCID 14938987 | — |
| Reactant | (S)-cyclopentyl 2-amino-4-methylpentanoate | HCID 53718217 | — |
| Reactant | Methanesulfonic acid 2-{4-[6-amino-5-(4-fluoro-benzoyl)-2-oxo-2H-pyridin-1-yl]-phenyl}-ethyl ester | HCID 58608538 | — |
| Product | Cyclopentyl N-[2-(3-{6-amino-5-[(4-fluorophenyl)carbonyl]-2-oxopyridin-1(2H)-yl}phenyl)ethyl]-L-leucinate | HCID 57658334 | — |
Reaction Steps
Example 70 was synthesised using similar methodology to Intermediate 4J (instead using 3-aminophenethyl alcohol) and L-Leucine cyclopentyl ester (Intermediate 8).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044211B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-734c844e101f480aa573bb3fe8d82c39 |
| Source note | uspto-grants-2011_10 |