HCID 57448196, compound → HCID 57448197, compound

HRID 1667601Notes

Reaction equation

HRID 1667601 reaction equation
[CH:1]([O:4][C:5]1[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][C:6]=1[CH2:7][NH:8][C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])([CH3:3])[CH3:2]>CO.[Pd]>[NH2:20][C:17]1[CH:18]=[CH:19][C:5]([O:4][CH:1]([CH3:3])[CH3:2])=[C:6]([CH:16]=1)[CH2:7][NH:8][C:9](=[O:15])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14]

Participants

4

Reactant 1

HCID 57448196HCID 57448196, compound

Product 1

HCID 57448197HCID 57448197, compoundYield 100.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To 8E (72 mg, 0.23 mmol) in MeOH (6 mL) was added Pd/C (cat.) and the mixture was hydrogenated at 55 psi overnight. The reaction was filtered and concentrated to provide 8F (65 mg, 99%). LC-MS: 303.22 (M+Na)+.

Workup

  1. customwas hydrogenated at 55 psi overnight
  2. filtrationThe reaction was filtered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-d9eb16bd4f1d4e0d8be93241ce1ee003
Source dataset
uspto-grants-2011_10
Patent number
US08044242B2

Reaction notes

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