Trifluoroacetic acid → HCID 57448198, compound

HRID 1667603Notes

Reaction equation

HRID 1667603 reaction equation
[CH3:1][O:2][C:3](=[O:24])[NH:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH:12]([CH3:14])[CH3:13])=[C:7]([CH2:15][NH:16]C(OC(C)(C)C)=O)[CH:6]=1.[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28]>C(Cl)Cl>[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28].[NH2:16][CH2:15][C:7]1[CH:6]=[C:5]([NH:4][C:3](=[O:24])[O:2][CH3:1])[CH:10]=[CH:9][C:8]=1[O:11][CH:12]([CH3:14])[CH3:13]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57700391HCID 57700391, compound

Product 1

HCID 57448198HCID 57448198, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

8G (17 mg, 0.05 mmol) was dissolved in CH2Cl2 (1 mL) and trifluoroacetic acid (0.2 mL) was added. After stirring at rt for 10 min, the reaction was concentrated to provide 8H (10 mg, 57%). LC-MS: 239.21 (M+H)+.

Workup

  1. concentrationthe reaction was concentrated
  2. customto provide 8H (10 mg, 57%)

Sources & evidence

ORD record
ord-229b8905f8f344c2b1abbd652016c255
Source dataset
uspto-grants-2011_10
Patent number
US08044242B2

Reaction notes

Loading…