HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 67444681, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 58007715 | HCID 58007715 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67444681 | HCID 67444681 | 88.1% |
Reaction Steps
A mixture of methyl N-{4-[4-(tert-butyl)benzyloxy]-4′-(trifluoromethoxy)biphenyl-3-yl}oxamate (436 mg, 0.869 mmol), methanol (2 ml), tetrahydrofuran (2 ml) and 2N aqueous sodium hydroxide (1.3 ml) was stirred at room temperature for 30 minutes. The precipitated solid was collected by filtration and washed with methanol to give the title compound (390 mg, 88.1%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044236B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-605310fae79c4077a1014459679a861b |
| Source note | uspto-grants-2011_10 |