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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1667641Generated: October 30, 2026

Methanol → HCID 67444681, compound

https://huagongshe.com/reaction/1667641

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantSodium HydroxideHCID 14798—
ReactantHCID 58007715HCID 58007715—
SolventTetrahydrofuranHCID 8028—
ProductHCID 67444681HCID 6744468188.1%

Reaction Steps

A mixture of methyl N-{4-[4-(tert-butyl)benzyloxy]-4′-(trifluoromethoxy)biphenyl-3-yl}oxamate (436 mg, 0.869 mmol), methanol (2 ml), tetrahydrofuran (2 ml) and 2N aqueous sodium hydroxide (1.3 ml) was stirred at room temperature for 30 minutes. The precipitated solid was collected by filtration and washed with methanol to give the title compound (390 mg, 88.1%) as a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08044236B2
Source datasetuspto-grants-2011_10
ORD IDord-605310fae79c4077a1014459679a861b
Source noteuspto-grants-2011_10