Methanol → HCID 67444681, compound

HRID 1667641Notes

Reaction equation

HRID 1667641 reaction equation
[C:1]([C:5]1[CH:36]=[CH:35][C:8]([CH2:9][O:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:26])[F:25])=[CH:19][CH:18]=3)=[CH:13][C:12]=2[NH:28][C:29](=[O:34])[C:30]([O:32]C)=[O:31])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:37]O.[OH-].[Na+:40]>O1CCCC1>[Na+:40].[CH3:37][N:28]([C:12]1[CH:13]=[C:14]([C:17]2[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:25])[F:26])=[CH:19][CH:18]=2)[CH:15]=[CH:16][C:11]=1[O:10][CH2:9][C:8]1[CH:35]=[CH:36][C:5]([C:1]([CH3:2])([CH3:4])[CH3:3])=[CH:6][CH:7]=1)[C:29](=[O:34])[C:30]([O-:32])=[O:31]

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 58007715HCID 58007715, compound

Product 1

HCID 67444681HCID 67444681, compoundYield 88.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of methyl N-{4-[4-(tert-butyl)benzyloxy]-4′-(trifluoromethoxy)biphenyl-3-yl}oxamate (436 mg, 0.869 mmol), methanol (2 ml), tetrahydrofuran (2 ml) and 2N aqueous sodium hydroxide (1.3 ml) was stirred at room temperature for 30 minutes. The precipitated solid was collected by filtration and washed with methanol to give the title compound (390 mg, 88.1%) as a white solid.

Workup

  1. filtrationThe precipitated solid was collected by filtration
  2. washwashed with methanol

Sources & evidence

ORD record
ord-605310fae79c4077a1014459679a861b
Source dataset
uspto-grants-2011_10
Patent number
US08044236B2

Reaction notes

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