Ammonium Hydroxide → HCID 86642792, compound

Participants

Reaction Steps

A solution of 14.5 g (0.068 mole) of 3-oxo-3(2-trifluoromethyl-phenyl)-propionitrile in 340 mL of sulfuric acid was stirred for 5 hours at room temperature. The mixture was slowly poured into ice water with stirring. The mixture was made basic by addition of ammonium hydroxide. The mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 13.82 g of 3-oxo-3-(2-trifluoromethyl-phenyl)-propionamide as a yellow solid.

Provenance & Evidence