Ammonium Hydroxide → HCID 86642792, compound

HRID 1667653Notes

Reaction equation

HRID 1667653 reaction equation
[O:1]=[C:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]([F:15])([F:14])[F:13])[CH2:3][C:4]#[N:5].[OH-:16].[NH4+]>S(=O)(=O)(O)O>[O:1]=[C:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]([F:13])([F:14])[F:15])[CH2:3][C:4]([NH2:5])=[O:16]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 126308073-Oxo-3-[2-(trifluoromethyl)phenyl]propanenitrile

Product 1

HCID 86642792HCID 86642792, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

A solution of 14.5 g (0.068 mole) of 3-oxo-3(2-trifluoromethyl-phenyl)-propionitrile in 340 mL of sulfuric acid was stirred for 5 hours at room temperature. The mixture was slowly poured into ice water with stirring. The mixture was made basic by addition of ammonium hydroxide. The mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 13.82 g of 3-oxo-3-(2-trifluoromethyl-phenyl)-propionamide as a yellow solid.

Workup

  1. extractionThe mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-49632fe424da4ce0aa23828e37023898
Source dataset
uspto-grants-2011_10
Patent number
US08044213B2

Reaction notes

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