反应详情

A mixture of 4.43 g (9.9 mmole) of 4-(3-chloro-phenyl)-2-(5-dimethoxymethyl-2-nitro-phenylamino)-thiazole-5-carboxylic acid amide (VI.2a), 80 mL of acetonitrile and 20 mL of 1 M hydrochloric acid was heated at 60 degrees for 2 hours. The mixture was diluted with 200 mL of ice-water. The precipitate was collected by filtration, washed with water, and air dried to give 3.3 g of 4-(3-chloro-phenyl)-2-(5-formyl-2-nitro-phenylamino)-thiazole-5-carboxylic acid amide (VI.2b) as an orange solid.

1. temperaturewas heated at 60 degrees for 2 hours
2. filtrationThe precipitate was collected by filtration
3. washwashed with water, and air
4. customdried