反应详情

A mixture of 0.240 g (0.98 mmole) of 1-dimethoxymethyl-5-fluoro-2-methoxy-4-nitro-benzene (IV.46d), 0.248 g (0.98 mmole) of 2-amino-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid amide (V.2), 0.956 g (2.94 mmole) of cesium carbonate and 5 mL of dimethylformamide was heated at 60 degrees for 3 hours. The mixture was cooled, poured into dilute ammonium chloride solution, and the precipitated orange solid was collected by filtration, washed with water, and air dried to give 0.286 g of 4-(3-chloro-phenyl)-2-(5-dimethoxymethyl-4-methoxy-2-nitro-phenylamino)-thiazole-5-carboxylic acid amide (VI.46a).

1. temperaturewas heated at 60 degrees for 3 hours
2. temperatureThe mixture was cooled
3. filtrationthe precipitated orange solid was collected by filtration
4. washwashed with water, and air
5. customdried