HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Phosphate, Dibasic → Ethyl 6-Iodoimidazo[1,2-b]pyridazine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Phosphate, Dibasic | HCID 24203 | — |
| Reactant | Ethyl bromopyruvate | HCID 66144 | — |
| Reactant | 6-Iodopyridazin-3-amine | HCID 10867834 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | Ethyl 6-Iodoimidazo[1,2-b]pyridazine-2-carboxylate | HCID 51063906 | 44% |
Reaction Steps
Using 3-amino-6-iodopyridazine (2.0 g, 9.05 mmol), N,N-dimethylacetamide (20 mL), ethyl 3-bromo-2-oxopropanate (1.82 mL, 14.5 mmol) and disodium hydrogenphosphate (3.21 g, 22.6 mmol), and in the same manner as in Reference Example 3, the title compound (1.2 g, 44%) was obtained as a green powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044049B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-89db384ab35449c090cf5cb001d38413 |
| Source note | uspto-grants-2011_10 |