Sodium Phosphate, Dibasic → Ethyl 6-Iodoimidazo[1,2-b]pyridazine-2-carboxylate

HRID 1667809Notes

Reaction equation

HRID 1667809 reaction equation
[NH2:1][C:2]1[N:3]=[N:4][C:5]([I:8])=[CH:6][CH:7]=1.Br[CH2:10][C:11](=O)[C:12]([O:14][CH2:15][CH3:16])=[O:13].P([O-])([O-])(O)=O.[Na+].[Na+]>CN(C)C(=O)C>[I:8][C:5]1[CH:6]=[CH:7][C:2]2[N:3]([CH:10]=[C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:1]=2)[N:4]=1

Participants

5

Reactant 3

HCID 24203Sodium Phosphate, DibasicHCID 66144Ethyl bromopyruvateHCID 108678346-Iodopyridazin-3-amine

Product 1

HCID 51063906Ethyl 6-Iodoimidazo[1,2-b]pyridazine-2-carboxylateYield 44%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

Using 3-amino-6-iodopyridazine (2.0 g, 9.05 mmol), N,N-dimethylacetamide (20 mL), ethyl 3-bromo-2-oxopropanate (1.82 mL, 14.5 mmol) and disodium hydrogenphosphate (3.21 g, 22.6 mmol), and in the same manner as in Reference Example 3, the title compound (1.2 g, 44%) was obtained as a green powder.

Sources & evidence

ORD record
ord-89db384ab35449c090cf5cb001d38413
Source dataset
uspto-grants-2011_10
Patent number
US08044049B2

Reaction notes

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