Hydrochloric Acid → 1-methyl-1H-1,2,3-triazole-4-carboxylic acid

HRID 1667814Notes

Reaction equation

HRID 1667814 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]([O:9]CC)=[O:8])[N:4]=[N:3]1.[OH-].[Na+].Cl>CO>[CH3:1][N:2]1[CH:6]=[C:5]([C:7]([OH:9])=[O:8])[N:4]=[N:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 21278002Ethyl 1-methyl-1H-1,2,3-triazole-4-carboxylate

Product 1

HCID 217664121-methyl-1H-1,2,3-triazole-4-carboxylic acidYield 50%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using ethyl 1-methyl-1H-1,2,3-triazole-4-carboxylate (1.48 g, 9.54 mmol), methanol (22 mL), 1N sodium hydroxide (15 mL) and 1N hydrochloric acid (15 mL) as starting materials and in the same manner as in Reference Example 12, the title compound (605 mg, 50%) was obtained as a white powder.

Sources & evidence

ORD record
ord-22b73dce74e04a03a2a009ad27dea8de
Source dataset
uspto-grants-2011_10
Patent number
US08044049B2

Reaction notes

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