Methanesulfonic Acid → HCID 86630644, compound

HRID 1667969Notes

Reaction equation

HRID 1667969 reaction equation
[CH:1]1([C:4]([NH:6][C:7]2[N:8]=[C:9]3[CH:14]=[CH:13][C:12]([O:15][C:16]4[CH:17]=[CH:18][C:19]([CH3:32])=[C:20]([NH:22][C:23]([C:25]5[N:29]([CH3:30])[N:28]=[C:27]([CH3:31])[CH:26]=5)=[O:24])[CH:21]=4)=[N:11][N:10]3[CH:33]=2)=[O:5])[CH2:3][CH2:2]1.[CH3:34][S:35]([OH:38])(=[O:37])=[O:36]>C(O)C>[CH3:34][S:35]([OH:38])(=[O:37])=[O:36].[CH:1]1([C:4]([NH:6][C:7]2[N:8]=[C:9]3[CH:14]=[CH:13][C:12]([O:15][C:16]4[CH:17]=[CH:18][C:19]([CH3:32])=[C:20]([NH:22][C:23]([C:25]5[N:29]([CH3:30])[N:28]=[C:27]([CH3:31])[CH:26]=5)=[O:24])[CH:21]=4)=[N:11][N:10]3[CH:33]=2)=[O:5])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 24767976Tak-593

Product 1

HCID 86630644HCID 86630644, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Using N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (2.00 g, 4.49 mmol), ethanol (80 mL) and methanesulfonic acid (0.34 mL, 4.71 mmol), and in the same manner as in Example 152, the title compound (1.63 g, 67%) was obtained as white crystals.

Sources & evidence

ORD record
ord-c82802f3c02c4ad092a2df9e75f2fe16
Source dataset
uspto-grants-2011_10
Patent number
US08044049B2

Reaction notes

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