3-Methyl-2-butenoyl chloride → HCID 57505585, compound

HRID 1668034Notes

Reaction equation

HRID 1668034 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][C:23]=1[CH3:24])[O:5][C:6]1[CH:7]=[CH:8][C:9]2[N:10]([CH:12]=[C:13]([NH:15][C:16]([CH:18]3[CH2:20][CH2:19]3)=[O:17])[N:14]=2)[N:11]=1.[CH3:25][C:26]([CH3:31])=[CH:27][C:28](Cl)=[O:29]>CN(C)C(=O)C>[CH3:24][C:23]1[CH:22]=[CH:21][C:4]([O:5][C:6]2[CH:7]=[CH:8][C:9]3[N:10]([CH:12]=[C:13]([NH:15][C:16]([CH:18]4[CH2:20][CH2:19]4)=[O:17])[N:14]=3)[N:11]=2)=[CH:3][C:2]=1[NH:1][C:28](=[O:29])[CH:27]=[C:26]([CH3:31])[CH3:25]

Participants

4

Reactant 2

HCID 1023943-Methyl-2-butenoyl chlorideHCID 57505476N-[6-(3-amino-4-methylphenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

Product 1

HCID 57505585HCID 57505585, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

Using N-[6-(3-amino-4-methylphenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide (200 mg, 0.62 mmol), N,N-dimethylacetamide (2.0 mL) and 3,3-dimethylacryloyl chloride (83 μL, 0.74 mmol), and in the same manner as in Example 120, the title compound (142 mg, 57%) was obtained as a white powder.

Sources & evidence

ORD record
ord-baf8f387ca7a4e5688f3d5af664af740
Source dataset
uspto-grants-2011_10
Patent number
US08044049B2

Reaction notes

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