Hydrochloric Acid → HCID 62595204, compound

HRID 1668279Notes

Reaction equation

HRID 1668279 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:9][CH:10]([NH:17]S(C(C)(C)C)=O)[C:11]2[CH:12]=[N:13][N:14]([CH3:16])[CH:15]=2)[CH:5]=[C:6]([CH3:8])[CH:7]=1.Cl>CO.O1CCOCC1>[CH3:1][C:2]1[CH:3]=[C:4]([CH2:9][CH:10]([NH2:17])[C:11]2[CH:12]=[N:13][N:14]([CH3:16])[CH:15]=2)[CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67350294HCID 67350294, compound

Product 1

HCID 62595204HCID 62595204, compoundYield 77%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of RS 2-methyl-propane-2-sulfinic acid [2-(3,5-dimethyl-phenyl)-1-(1-methyl-1H-pyrazol-4-yl)-ethyl]-amide (2.0 g) in methanol (12 ml) was treated with a solution of hydrogenchloride in dioxane (12 ml, 4 N) at room temperature overnight. The reaction mixture was quenched with aqueous potassium carbonate solution and adjusted to pH 8-9, extracted and the organic phases dried over magnesium sulfate. After evaporation of the solvent a yellowish oil was obtained in 77% yield (1.05 g).

Workup

  1. customThe reaction mixture was quenched with aqueous potassium carbonate solution
  2. extractionextracted
  3. dry with materialthe organic phases dried over magnesium sulfate
  4. customAfter evaporation of the solvent a yellowish oil
  5. customwas obtained in 77% yield (1.05 g)

Sources & evidence

ORD record
ord-4eac18d7e6fd4a71b9ac6f4d56a48bca
Source dataset
uspto-grants-2011_08
Patent number
US07989394B2

Reaction notes

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